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OSTENIL PLUS must not be administered simultaneously or mixed with other intraarticular injections. In particular, in vitro studies suggest that the properties of hyaluronic acid may be altered by different agents such as corticosteroids, lidocaine, or iodinated contrast agents.
In vivo studies have indicated that hyaluronic acid may extend the effect of certain local anesthetics.
Moreover, the product must not be used concomitantly with disinfectants containing quaternary ammonium salts, because hyaluronic acid can precipitate in their presence.
